Enzyme-free colorimetric assay of serum uric acid

Chem Commun (Camb). 2011 Nov 7;47(41):11498-500. doi: 10.1039/c1cc13349g. Epub 2011 Sep 20.

Abstract

A nonenzymatic method for the selective detection and quantification of serum uric acid (UA) using 2-thiouracil (2-TU) tailored Au nanoparticles is developed. The H-bonding interaction of UA with functionalized Au nanoparticles brings instantaneous visible color change and paves the way for the visible sensing of UA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorimetry / methods
  • Gold / chemistry*
  • Hydrogen Bonding
  • Metal Nanoparticles / chemistry*
  • Spectrophotometry, Ultraviolet
  • Thiouracil / analogs & derivatives
  • Thiouracil / chemistry
  • Uric Acid / blood*

Substances

  • Uric Acid
  • Thiouracil
  • Gold