Peli1 (rel)ieves autoimmunity

Nat Immunol. 2011 Sep 20;12(10):927-9. doi: 10.1038/ni.2108.

Abstract

T cell tolerance is essential to the prevention of autoimmunity. The ubiquitin E3 ligase Peli1 acts as a negative regulator of T cell activation and contributes to the maintenance of self-tolerance.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Autoimmunity*
  • Lymphocyte Activation*
  • Nuclear Proteins / physiology*
  • T-Lymphocytes / immunology*
  • Ubiquitin-Protein Ligases

Substances

  • Nuclear Proteins
  • Ubiquitin-Protein Ligases
  • Peli1 protein, mouse