Abstract
T cell tolerance is essential to the prevention of autoimmunity. The ubiquitin E3 ligase Peli1 acts as a negative regulator of T cell activation and contributes to the maintenance of self-tolerance.
MeSH terms
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Animals
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Autoimmunity*
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Lymphocyte Activation*
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Nuclear Proteins / physiology*
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T-Lymphocytes / immunology*
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Ubiquitin-Protein Ligases
Substances
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Nuclear Proteins
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Ubiquitin-Protein Ligases
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Peli1 protein, mouse