Abstract
A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana led to the isolation and identification of three new triterpenoids, 2 α,3 α,19 α-trihydroxy-urs-12-en-24-formyl-28-oic acid (1), 2 α,3 β,21 α-trihydroxy-urs-12-en-28-oic acid ( 2), and 3 β-acetyloxy-1-oxo-olean-12-en-28-oic acid (3), along with seven known triterpenoids (4-10). The structures of these new compounds were determined through spectral analysis, including extensive 2D-NMR data. The new compounds 1-3 showed significant cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cell lines with IC(50) values ranging from 7.17 to 48.73 µM.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Berberis / chemistry*
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Cell Line, Tumor
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Humans
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Molecular Structure
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Neoplasms / drug therapy*
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Terpenes / isolation & purification
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Terpenes / pharmacology
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Terpenes / therapeutic use*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
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Triterpenes / therapeutic use*
Substances
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2alpha,3alpha,19alpha-trihydroxy-urs-12-en-24-formyl-28-oic acid
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2alpha,3beta,21alpha-trihydroxy-urs-12-en-28-oic acid
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3beta-acetyloxy-1-oxo-olean-12-en-28-oic acid
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Terpenes
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Triterpenes