Development of a knowledge assessment tool for dermatotoxicity caused by inhibitors of epidermal growth factor receptor

Support Care Cancer. 2012 Aug;20(8):1667-71. doi: 10.1007/s00520-011-1257-y. Epub 2011 Sep 18.

Abstract

Purpose: The aim of this study was the development of a knowledge assessment tool for dermatotoxicity caused by inhibitors of EGFR (intravenous regimens).

Methods: Five nurses with experience in oncology created a 25-item questionnaire. The questionnaire was presented to six experts for assessment of face and content validity. Item analysis and reliability testing were evaluated on the test results of 76 nurses.

Results: Face and content validity was achieved for 25 items. Two items with low biserial correlations were deleted. The values for item difficulty range from 0.2 to 0.7. The values for item discrimination ranged from 0.25 to 0.64. The complete post-tested 23-item questionnaire showed excellent internal consistency with Kuder-Richardson 20 score of 0.909. The Cohen κ tests showed that the questionnaire has very good test-retest reliability. The specific tool can be used in several studies, leading to the development of educational interventions.

MeSH terms

  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal / adverse effects*
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Cetuximab
  • ErbB Receptors / antagonists & inhibitors*
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Infusions, Intravenous
  • Neoplasms / drug therapy*
  • Neoplasms / nursing*
  • Panitumumab
  • Quality of Life
  • Reproducibility of Results
  • Surveys and Questionnaires*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Panitumumab
  • ErbB Receptors
  • Cetuximab