Shedding light by cancer redox-human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

Chem Commun (Camb). 2011 Oct 28;47(40):11264-6. doi: 10.1039/c1cc14578a. Epub 2011 Sep 19.

Abstract

A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cell Line, Tumor
  • Enzyme Activation
  • Enzyme Assays / methods*
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / metabolism*
  • Humans
  • Morpholines / chemistry
  • Oxidation-Reduction
  • Quinone Reductases / metabolism*
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Morpholines
  • morpholine
  • NADH dehydrogenase (quinone)
  • Quinone Reductases