Loss of Akt1 evokes epithelial-mesenchymal transition by autocrine regulation of transforming growth factor-β1

Adv Biol Regul. 2012 Jan;52(1):88-96. doi: 10.1016/j.advenzreg.2011.09.013.

Authors

Eun Kyoung Kim¹, Sung Ji Yun, Jung Min Ha, Young Whan Kim, In Hye Jin, Dae Han Woo, Sang Hun Song, Hong Koo Ha, Yoon Sup Choi, Taehoon G Lee, Sun Sik Bae

Affiliation

¹ MRC for Ischemic Tissue Regeneration, Medical Research Institute, Department of Pharmacology, School of Medicine, Pusan National University, Bumeo-ri, Mulgeum-eup, Yangsan-si, Yangsan, Kyungnam 626-870, Republic of Korea.

PMID: 21925532
DOI: 10.1016/j.advenzreg.2011.09.013

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blotting, Western
Cell Line, Tumor
Cell Movement / genetics
Cell Movement / physiology
Epithelial-Mesenchymal Transition / genetics
Epithelial-Mesenchymal Transition / physiology*
Gene Silencing / physiology
Humans
Immunohistochemistry
Proto-Oncogene Proteins c-akt / genetics
Proto-Oncogene Proteins c-akt / metabolism*
Transforming Growth Factor beta1 / genetics
Transforming Growth Factor beta1 / metabolism*

Substances

Transforming Growth Factor beta1
Proto-Oncogene Proteins c-akt