SIP-ing the elixir of youth

William Mair; Kristan K Steffen; Andrew Dillin

doi:10.1016/j.cell.2011.08.026

SIP-ing the elixir of youth

Cell. 2011 Sep 16;146(6):859-60. doi: 10.1016/j.cell.2011.08.026.

Authors

William Mair¹, Kristan K Steffen, Andrew Dillin

Affiliation

¹ The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. wmair@hsph.harvard.edu

PMID: 21925309
DOI: 10.1016/j.cell.2011.08.026

Abstract

AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity.

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