HCMV grabs a mechanism to escape neutralization

Cell Host Microbe. 2011 Sep 15;10(3):177-8. doi: 10.1016/j.chom.2011.08.011.

Abstract

The HCMV-neutralizing monoclonal antibody MSL-109 failed to prevent HCMV-induced disease in the clinic. In this issue of Cell Host & Microbe, Manley et al. (2011) found that MSL-109 rapidly induces antibody resistance by a nongenetic mechanism. Their results shed light on how antibodies can interact with their targets both outside and inside infected cells and virions.

Publication types

  • Comment

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • Antibodies, Viral / immunology*
  • Cytomegalovirus / physiology*
  • Cytomegalovirus Infections / immunology*
  • Host-Pathogen Interactions*
  • Humans
  • Virion / physiology*
  • Virus Assembly*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral