[Osteoblast-osteoclast interaction mechanisms]

José A Riancho; Jesús Delgado-Calle

doi:10.1016/j.reuma.2011.03.003

[Osteoblast-osteoclast interaction mechanisms]

Reumatol Clin. 2011 Sep:7 Suppl 2:S1-4. doi: 10.1016/j.reuma.2011.03.003. Epub 2011 Aug 4.

[Article in Spanish]

Authors

José A Riancho¹, Jesús Delgado-Calle

Affiliation

¹ Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla-IFIMAV, Universidad de Cantabria, Santander, España. rianchoj@unican.es

PMID: 21924211
DOI: 10.1016/j.reuma.2011.03.003

Abstract

Bone tissue is constantly renewed by the coordinated action of osteoclasts and osteoblasts. Osteocytes have a prominent role in the onset of bone remodeling at selected sites of the skeleton. These and other osteoblastic cells produce a variety of mediators that modulate the differentiation of osteoclast precursors, a critical step for bone resorption to occur. Among them, M-CSF and RANKL are especially important.

Publication types

English Abstract

MeSH terms

Bone Remodeling / physiology*
Cell Communication*
Humans
Osteoblasts / physiology*
Osteoclasts / physiology*
Osteoprotegerin / physiology
RANK Ligand / physiology
Receptor Activator of Nuclear Factor-kappa B / physiology

Substances

Osteoprotegerin
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
TNFSF11 protein, human