Objective: To review the research status of the neovascularization of adipose tissue engineering in the past decade so as to provide theoretical references for the development of the rapid revascularization of tissue engineered adipose.
Methods: The literature about the revascularization of adipose tissue engineering was extensively reviewed and analyzed, centering on 5 elements: specificity of histological structures and blood supply, revascularization mechanism, coculture of different seed cells, modification of scaffold, and microenvironment.
Results: Adipose tissue engineering offers a new solution for soft tissue defects. However, there is still the unfulfilled need in the size of engineered adipose tissue (less than 1 mL), which was determined by the degree of neovascularization in engineered tissue. Overall, rapid neovascularization in engineering tissue is a key link of experimental study changing into clinical application.
Conclusion: Providing a sufficient supply with nutrients and oxygen by means of a sufficient and rapid neovascularization will be at the heart of any attempts to obtain bigger tissue engineered adipose to meet the demand of repairing large soft tissue defect.