Copper-catalyzed coupling of oxime acetates with aldehydes: a new strategy for synthesis of pyridines

Zhi-Hui Ren; Zhi-Yuan Zhang; Bing-Qin Yang; Yao-Yu Wang; Zheng-Hui Guan

doi:10.1021/ol202290y

Copper-catalyzed coupling of oxime acetates with aldehydes: a new strategy for synthesis of pyridines

Org Lett. 2011 Oct 7;13(19):5394-7. doi: 10.1021/ol202290y. Epub 2011 Sep 13.

Authors

Zhi-Hui Ren¹, Zhi-Yuan Zhang, Bing-Qin Yang, Yao-Yu Wang, Zheng-Hui Guan

Affiliation

¹ Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.

PMID: 21913647
DOI: 10.1021/ol202290y

Abstract

Copper-catalyzed coupling of oxime acetates with aldehydes offers a new strategy for the synthesis of highly substituted pyridines. This novel method tolerates a wide range of functionality and allows for rapid elaboration of the oxime acetates into a variety of substituted pyridines.