Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Despite the substantial progress that has been achieved, the precise mechanisms involved in the development of this disease are still not fully understood. The most common concepts relate to the genetic background and environmental/toxic effects. A number of model systems have been introduced, which mimic the human disease to varying extents. In this chapter, we introduce some of the most widely accepted protocols of the pharmacological models of Parkinson's disease.