Abstract
A Zn(2+) tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, and shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) and lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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DNA / metabolism*
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HeLa Cells
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Humans
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Macrocyclic Compounds / chemistry*
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Models, Molecular
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Molecular Conformation
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology
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Spectrometry, Fluorescence
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Zinc / chemistry*
Substances
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Antineoplastic Agents
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Macrocyclic Compounds
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Organometallic Compounds
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DNA
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Zinc