A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

Chem Commun (Camb). 2011 Oct 28;47(40):11330-2. doi: 10.1039/c1cc14107d. Epub 2011 Sep 13.

Abstract

A Zn(2+) tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, and shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) and lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • DNA / metabolism*
  • HeLa Cells
  • Humans
  • Macrocyclic Compounds / chemistry*
  • Models, Molecular
  • Molecular Conformation
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology
  • Spectrometry, Fluorescence
  • Zinc / chemistry*

Substances

  • Antineoplastic Agents
  • Macrocyclic Compounds
  • Organometallic Compounds
  • DNA
  • Zinc