Novel hybrid vesicles co-assembled from a cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release

Chem Commun (Camb). 2011 Oct 21;47(39):10978-80. doi: 10.1039/c1cc14793e. Epub 2011 Sep 12.

Abstract

This work presents an important example of novel hybrid vesicles with pH-triggered transmembrane channels prepared by co-assembly of poly(acrylic acid)-g-poly(monomethoxy ethylene glycol) (PAAc-g-mPEG) with a cationic lipid, didodecyldimethylammonium bromide (DDAB), via electrostatic interaction for effective doxorubicin (DOX) release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry*
  • Cell Membrane / metabolism*
  • Delayed-Action Preparations
  • Doxorubicin / chemistry
  • Doxorubicin / metabolism
  • Drug Carriers / chemistry*
  • Hydrogen-Ion Concentration
  • Models, Molecular
  • Molecular Conformation
  • Particle Size
  • Polyethylene Glycols / chemistry*
  • Quaternary Ammonium Compounds / chemistry*

Substances

  • Acrylic Resins
  • Delayed-Action Preparations
  • Drug Carriers
  • Quaternary Ammonium Compounds
  • didodecyldimethylammonium
  • Polyethylene Glycols
  • carbopol 940
  • Doxorubicin
  • monomethoxypolyethylene glycol