A 76-year-old male patient with an angioimmunoblastic T-cell lymphoma under treatment with fludarabine was referred because of scrotal ulcers, evolving for several months. Respiratory, gastrointestinal, and urinary symptoms were denied. Histopathological examination showed the presence of a chronic inflammatory process with epithelioid granulomas. Ziehl-Neelsen stain was positive for acid-fast bacilli. PCR analysis allowed the identification of a mycobacteria strain belonging to the Mycobaterium tuberculosis complex. Skin biopsy was repeated and culture revealed M. tuberculosis sensitive to traditional tuberculostatic drugs. This bacteria was also isolated in bronchial and urinary specimens. Although no abnormal findings were detected on chest radiography or abdominal ultrasonography, scrotal ultrasound showed areas of nodular thickening in the lower part of the epididymis. The diagnosis of cutaneous, lung, and genitourinary tuberculosis was made and the patient was treated with multidrug therapy (rifampicin 600 mg/day, isoniazid 250 mg/day, pyrazinamide 1500 mg/day, and ethambutol 1200 mg/day for the first 2 months, followed by rifampicin and isoniazid with the same dosages for the subsequent 7 months). Complete resolution of skin lesions was observed after two months of treatment. Diagnosis and treatment modalities are discussed. This case emphasizes the importance of considering tuberculosis in the differential diagnosis of genital ulcer.