Carcinoid syndrome from small bowel endocrine carcinoma in the absence of hepatic metastasis

Age Ageing. 2011 Nov;40(6):760-2. doi: 10.1093/ageing/afr122. Epub 2011 Sep 7.

Abstract

An 80-year-old male patient presented with abdominal pain, paroxysmal diaphoresis, diarrhoea and vomiting. CT scan revealed a small bowel endocrine carcinoma (or 'carcinoid' tumour), but the absence of hepatic disease. The lesion was excised 'en-bloc'. Intra-operatively, there was wide fluctuation in blood pressure associated with tumour manipulation, with hyper- and hypotension. Carcinoid syndrome usually occurs from gastrointestinal tumours when hepatic metastases occur, causing flushing, diarrhoea, bronchoconstriction and murmurs from cardiac valvular lesions. This patient did not have radiological evidence of hepatic metastasis, but the syndrome could still occur with midgut tumours via local invasion of the retroperitoneal circulation, or by action of substances other than serotonin that do not undergo hepatic metabolism.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Carcinoid Tumor / complications*
  • Carcinoid Tumor / diagnostic imaging
  • Carcinoid Tumor / surgery
  • Digestive System Surgical Procedures
  • Humans
  • Ileal Neoplasms / complications*
  • Ileal Neoplasms / diagnostic imaging
  • Ileal Neoplasms / surgery
  • Male
  • Malignant Carcinoid Syndrome / diagnosis
  • Malignant Carcinoid Syndrome / etiology*
  • Tomography, X-Ray Computed
  • Treatment Outcome