Abstract
The cinchona alkaloid-catalyzed γ-amination of α,β-unsaturated acyl chlorides with azodicarboxylates to give the corresponding dihydropyridazinones in good yields with high enantioselectivities has been developed. Reductive ring opening of the dihydropyridazinones afforded series of cyclic and acyclic γ-amino acid derivatives in good yields with high enantiopurity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amination
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Amino Acids / chemical synthesis*
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Amino Acids / chemistry
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Carboxylic Acids / chemistry*
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Catalysis
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Chlorides / chemistry*
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Cinchona Alkaloids / chemistry*
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Pyridazines / chemical synthesis
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Pyridazines / chemistry*
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Stereoisomerism
Substances
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Amino Acids
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Carboxylic Acids
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Chlorides
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Cinchona Alkaloids
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Pyridazines