Abstract
Several 2,5-disubstituted-1,3,4-oxadiazoles (4a-f) and 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (7a-f) were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound 7c showed excellent anti-inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid peroxidation activity when compared with ibuprofen.
MeSH terms
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Analgesics* / chemical synthesis
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Analgesics* / chemistry
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Analgesics* / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal* / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal* / chemistry
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Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
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Female
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Magnetic Resonance Spectroscopy
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Male
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Mass Spectrometry
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Mice
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Oxadiazoles* / chemical synthesis
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Oxadiazoles* / chemistry
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Oxadiazoles* / pharmacology
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Spectroscopy, Fourier Transform Infrared
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Stomach Ulcer / chemically induced*
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Thiazoles* / chemical synthesis
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Thiazoles* / chemistry
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Thiazoles* / pharmacology
Substances
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Analgesics
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Anti-Inflammatory Agents, Non-Steroidal
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Oxadiazoles
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Thiazoles