A general method for synthesis of GPI anchors illustrated by the total synthesis of the low-molecular-weight antigen from Toxoplasma gondii

Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9961-4. doi: 10.1002/anie.201103483. Epub 2011 Sep 5.

Abstract

Building blocks: a new, general synthetic strategy, which allows the construction of branched glycosylphosphatidylinositols (GPIs), enables the synthesis of parasitic glycolipid 1 from Toxoplasma gondii. In addition, the structure is further confirmed by recognition of monoclonal antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens / chemistry*
  • Carbohydrate Conformation
  • Glycosylphosphatidylinositols / chemical synthesis*
  • Glycosylphosphatidylinositols / chemistry
  • Molecular Sequence Data
  • Molecular Weight
  • Toxoplasma / chemistry*

Substances

  • Antigens
  • Glycosylphosphatidylinositols