A novel pH-sensitive (±)-α-tocopherol-5-fluorouracil adduct with antioxidant and anticancer properties

Chem Commun (Camb). 2011 Oct 14;47(38):10713-5. doi: 10.1039/c1cc13821a. Epub 2011 Sep 5.

Abstract

A novel pH-sensitive (±)-α-tocopherol-5-fluorouracil (VE-5-FU) adduct with antioxidant and anticancer properties for antioxidant-based cancer chemoprevention was synthesized and utilized for selective drug release in the stomach.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / toxicity
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Antioxidants / toxicity
  • Binding Sites
  • Cell Proliferation / drug effects
  • Chemoprevention
  • Computer Simulation
  • Fluorouracil / analogs & derivatives*
  • Fluorouracil / chemistry
  • Fluorouracil / therapeutic use
  • Fluorouracil / toxicity
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Neoplasms / drug therapy
  • Serum Albumin / chemistry
  • Stereoisomerism
  • Tocopherols / chemistry*
  • Tocopherols / therapeutic use
  • Tocopherols / toxicity

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Serum Albumin
  • alpha-tocopherol-5-fluorouracil
  • Tocopherols
  • Fluorouracil