Abstract
A novel pH-sensitive (±)-α-tocopherol-5-fluorouracil (VE-5-FU) adduct with antioxidant and anticancer properties for antioxidant-based cancer chemoprevention was synthesized and utilized for selective drug release in the stomach.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / toxicity
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Antioxidants / chemistry*
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Antioxidants / pharmacology*
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Antioxidants / toxicity
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Binding Sites
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Cell Proliferation / drug effects
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Chemoprevention
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Computer Simulation
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Fluorouracil / analogs & derivatives*
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Fluorouracil / chemistry
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Fluorouracil / therapeutic use
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Fluorouracil / toxicity
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Neoplasms / drug therapy
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Serum Albumin / chemistry
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Stereoisomerism
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Tocopherols / chemistry*
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Tocopherols / therapeutic use
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Tocopherols / toxicity
Substances
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Antineoplastic Agents
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Antioxidants
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Serum Albumin
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alpha-tocopherol-5-fluorouracil
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Tocopherols
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Fluorouracil