Abstract
The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources.
Copyright © 2011 Elsevier GmbH. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antifungal Agents / pharmacology
-
Antifungal Agents / therapeutic use
-
Aspergillus fumigatus / drug effects
-
Aspergillus fumigatus / genetics
-
Aspergillus fumigatus / immunology*
-
Biomarkers / analysis
-
Candida albicans / drug effects
-
Candida albicans / genetics
-
Candida albicans / immunology*
-
Communicable Diseases / drug therapy
-
Communicable Diseases / immunology*
-
Communicable Diseases / microbiology
-
Communicable Diseases / pathology
-
Cytokines / immunology
-
Drug Design*
-
Genetic Variation
-
Genome, Fungal*
-
Host-Pathogen Interactions / drug effects
-
Host-Pathogen Interactions / immunology
-
Humans
-
Immune Evasion
-
Immune Tolerance
-
Microarray Analysis
-
Molecular Targeted Therapy
-
Mycoses / drug therapy
-
Mycoses / immunology*
-
Mycoses / microbiology
-
Mycoses / pathology
-
Proteomics / methods*
-
Receptors, Pattern Recognition / genetics
-
Receptors, Pattern Recognition / immunology
-
Systems Biology / methods*
-
Th1 Cells / immunology
-
Th17 Cells / immunology
Substances
-
Antifungal Agents
-
Biomarkers
-
Cytokines
-
Receptors, Pattern Recognition