Abstract
36 Novel heterocyclic chalcone derivatives were synthesized and tested for their anti-bacterial activity. Some compounds presented good anti-microbial activities against Gram-positive bacteria (including the multidrug-resistant clinical isolates). This class of compounds presented high potency against Streptococcus mutans, among which the derivatives F2 with an MIC of 2 µg/mL was as active as the standard drug (norfloxacin) and less active than oxacillin. All the compounds did not inhibit the growth of Gram-negative bacteria (Escherichia coli CCARM 1924 or Escherichia coli CCARM 1356) at 64 µg/mL.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Chalcone / analogs & derivatives*
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Chalcone / chemical synthesis*
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Chalcone / chemistry
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Chalcone / pharmacology
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Drug Design*
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Drug Resistance, Multiple, Bacterial / drug effects
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Furans / chemistry*
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / growth & development
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Gram-Negative Bacteria / isolation & purification
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Gram-Positive Bacteria / drug effects
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Gram-Positive Bacteria / growth & development
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Gram-Positive Bacteria / isolation & purification
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Microbial Sensitivity Tests
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Molecular Structure
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Quinolines / chemistry*
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Sulfur Compounds / chemistry*
Substances
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Anti-Bacterial Agents
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Furans
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Quinolines
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Sulfur Compounds
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Chalcone
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quinoline
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furan