Fluoropolymer based tile and fabric spray sealants were evaluated for the release of airborne fluoropolymer constituents and volatile organic compounds (VOCs) during typical product use scenarios in a simulated bathroom and a simulated recreational vehicle. Fluoride was quantified after oxygen bomb digestion of airborne spray collected from personal, area, and surface samples. VOCs were quantified by gas chromatography/mass spectrometry (GC/MS) and gas chromatography/flame ionization spectrometry (GC/FID). Tile grout sealant contained approximately 1% acrylic fluoropolymer resin and 90% VOCs not including propellants. VOCs were short- and medium- chain methylated isoparaffinic hydrocarbons. When horizontally spraying a bathroom shower floor, grout spray sealant released a non-detectable amount of fluoride (<0.8 µg/m3) and 400-1400 mg/m3 total VOCs. When vertically spraying a shower wall, up to 2.0 µg/m3 of fluoride and from 1000 to 2300 mg/m3 total VOCs were detected. Fabric spray sealant contained 1% acrylic fluoropolymer resin and approximately 90% VOCs including perchloroethylene (PERC). Fabric spray released from 0.5 to 2.3 µg/m3 fluoride inside a recreational vehicle in the absence of crosswinds and less than 0.5 µg/m3 fluoride in the presence of a 10 mph crosswind. VOC release measured 240-938 mg/m3 without crosswinds and 161-522 mg/m3 with crosswinds. These studies show that fluoropolymer constituents from fluorinated spray sealants were near non-detectable levels in the breathing zone in nearly all samples while VOCs were measured at elevated levels (>400 mg/m3). The toxicological consequences of elevated VOCs during sealant spraying and the effects of certain fluoropolymer constituents are discussed.