Highly efficient continuous flow reactions using singlet oxygen as a "green" reagent

François Lévesque; Peter H Seeberger

doi:10.1021/ol2017643

Highly efficient continuous flow reactions using singlet oxygen as a "green" reagent

Org Lett. 2011 Oct 7;13(19):5008-11. doi: 10.1021/ol2017643. Epub 2011 Aug 31.

Authors

François Lévesque¹, Peter H Seeberger

Affiliation

¹ Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany.

PMID: 21879739
DOI: 10.1021/ol2017643

Abstract

Described is a new method for the efficient in situ production of singlet oxygen in a simple continuous flow photochemical reactor. The extremely large interfacial area generated by running the biphasic mixture in a narrow channel at a high flow rate ensures high throughput as well as fast and efficient oxidation of various alkenes, 1,3-dienes, and thioethers on a preparative scale.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Molecular Structure
Oxidation-Reduction
Photochemistry / methods*
Singlet Oxygen / chemistry*

Substances

Singlet Oxygen