The purpose of this study was to investigate the meaning and knowledge level and practices of emergency nurses in Jordan in relation to drug-seeking behaviors in the emergency units in Jordan. A descriptive correlation design was used. Data were collected using self-report questionnaires from 305 emergency nurses, employed in different emergency departments (EDs) in Jordan. The results of this study revealed that the ED nurses had a moderate level of ability to describe patients with drug-seeking behaviors, had moderate agreement on the behaviors that may suggest drug seeking, and a moderate level of knowledge related to drug-seeking behaviors. The analyses also showed that the ED nurses had negative attitudes toward drug-seeking behaviors, and lacked the ability to manage drug-seeking behaviors, when identified. Nurses in the EDs who completed the questionnaires identified a need for more drug seeking-behavior knowledge and skills to assess and manage this condition more effectively.