Abstract
Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / biosynthesis*
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Adenosine Triphosphate / metabolism
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Antitubercular Agents / pharmacology*
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Cell Membrane / drug effects*
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Cell Membrane / metabolism*
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Mycobacterium bovis / drug effects
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Mycobacterium bovis / metabolism
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Proton-Motive Force / drug effects*
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Pyrazinamide / analogs & derivatives*
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Pyrazinamide / pharmacology
Substances
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Antitubercular Agents
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Pyrazinamide
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pyrazinoic acid
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Adenosine Triphosphate