Abstract
The Hotoda's sequence substituted with TBDPS via 5'-end nucleobase existed as parallel quadruplex structure and exhibited inhibitory activities in an HIV-1 envelop proteins mediated cell-cell fusion assay. This result demonstrated that the 5'-aromatic groups of the Hotoda's sequence are allowed to have a large spatial freedom and remain to be optimized for its role in the binding to HIV-1 envelop proteins.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Composition
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Cell Fusion*
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G-Quadruplexes*
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HIV Fusion Inhibitors / chemical synthesis*
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HIV Fusion Inhibitors / chemistry
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HIV Fusion Inhibitors / metabolism
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HIV Fusion Inhibitors / pharmacology*
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HIV-1 / drug effects*
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HIV-1 / physiology
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Humans
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Hydrophobic and Hydrophilic Interactions
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Membrane Fusion
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Protein Binding
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Structure-Activity Relationship
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env Gene Products, Human Immunodeficiency Virus / antagonists & inhibitors*
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env Gene Products, Human Immunodeficiency Virus / chemistry
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env Gene Products, Human Immunodeficiency Virus / metabolism
Substances
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HIV Fusion Inhibitors
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env Gene Products, Human Immunodeficiency Virus