Synthesis, characterization and application of a two-fold 13C-labeled calibration standard for the analysis of arsenobetaine using HPLC-ESI-MS/MS without high resolution mass spectrometry

S Lischka; F Körte; R Faust; I Nehls; Ch Piechotta

doi:10.1016/j.talanta.2011.07.047

Synthesis, characterization and application of a two-fold 13C-labeled calibration standard for the analysis of arsenobetaine using HPLC-ESI-MS/MS without high resolution mass spectrometry

Talanta. 2011 Sep 30;85(4):1996-9. doi: 10.1016/j.talanta.2011.07.047. Epub 2011 Jul 19.

Authors

S Lischka¹, F Körte, R Faust, I Nehls, Ch Piechotta

Affiliation

¹ BAM - Federal Institute for Materials Research and Testing, Department of Analytical Chemistry, Reference Materials, Organic Trace Analysis, Richard-Willstätter-Str. 11, 12489 Berlin, Germany. susanne.lischka@bam.de

PMID: 21872050
DOI: 10.1016/j.talanta.2011.07.047

Abstract

A procedure has been developed for the determination of arsenobetaine in fish matrix by HPLC-ESI-MS/MS. Hereby (trimethylarsonium)-1,2-(13)C-acetate (arsenobetaine) is used as internal calibration standard. Arsenobetaine was determined in a fish material (Sea Bass) with an expanded uncertainty of 3.8%.

MeSH terms

Arsenicals / analysis*
Arsenicals / chemistry*
Calibration
Carbon Isotopes / chemistry
Chromatography, High Pressure Liquid / standards*
Reference Standards
Spectrometry, Mass, Electrospray Ionization / standards*
Tandem Mass Spectrometry / standards*

Substances

Arsenicals
Carbon Isotopes
arsenobetaine