Does human bocavirus infection depend on helper viruses? A challenging case report

Virol J. 2011 Aug 29:8:417. doi: 10.1186/1743-422X-8-417.

Abstract

A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV) and human herpes virus type 6 (HHV6) is reported. The case supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or that HBoV replicates by a mechanism that is atypical for parvoviruses, or that HBoV infection can be specifically treated with cidofovir.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use
  • Cidofovir
  • Coinfection / diagnosis
  • Coinfection / drug therapy
  • Coinfection / pathology
  • Coinfection / virology*
  • Cytosine / administration & dosage
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • DNA, Viral / analysis
  • Diarrhea / diagnosis
  • Diarrhea / drug therapy
  • Diarrhea / pathology
  • Diarrhea / virology*
  • Helper Viruses / drug effects
  • Helper Viruses / physiology*
  • Herpesvirus 6, Human / drug effects
  • Herpesvirus 6, Human / physiology*
  • Human bocavirus / drug effects
  • Human bocavirus / physiology*
  • Humans
  • Infant
  • Male
  • Organophosphonates / administration & dosage
  • Organophosphonates / therapeutic use*
  • Parvoviridae Infections / diagnosis
  • Parvoviridae Infections / drug therapy
  • Parvoviridae Infections / pathology
  • Parvoviridae Infections / virology*
  • Polymerase Chain Reaction
  • Roseolovirus Infections / diagnosis
  • Roseolovirus Infections / drug therapy
  • Roseolovirus Infections / pathology
  • Roseolovirus Infections / virology*
  • Viral Load / drug effects

Substances

  • Antiviral Agents
  • DNA, Viral
  • Organophosphonates
  • Cytosine
  • Cidofovir