Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus

Nico Ueberschaar; Basile Le Sage Tchize Ndejouong; Ling Ding; Armin Maier; Heinz-Herbert Fiebig; Christian Hertweck

doi:10.1016/j.bmcl.2011.07.108

Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5839-41. doi: 10.1016/j.bmcl.2011.07.108. Epub 2011 Aug 4.

Authors

Nico Ueberschaar¹, Basile Le Sage Tchize Ndejouong, Ling Ding, Armin Maier, Heinz-Herbert Fiebig, Christian Hertweck

Affiliation

¹ Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr, 11a, D-07745 Jena, Germany.

PMID: 21868221
DOI: 10.1016/j.bmcl.2011.07.108

Abstract

Three unusual alkyhydrazide natural products, named hydrazidomycin A (1), B (2) and C (3), were isolated from the chloroform extract of a Streptomycesatratus culture, and their structures were elucidated by MS and NMR techniques. Hydrazidomycins A-C exhibited moderate to strong cytotoxic activities in a panel of 42 cell lines, with hydrazidomycin A being the most potent compound (mean IC(50)=0.37 μM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / isolation & purification
Antibiotics, Antineoplastic / pharmacology*
Cell Line, Tumor
Drug Discovery
Drug Screening Assays, Antitumor
Female
Humans
Hydrazines / chemistry*
Hydrazines / isolation & purification
Hydrazines / pharmacology*
Inhibitory Concentration 50
Male
Molecular Structure
Streptomyces / chemistry*

Substances

Antibiotics, Antineoplastic
Hydrazines
hydrazidomycin A