Abstract
The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Arctium / chemistry*
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Butylamines / chemistry
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Cell Line, Tumor
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Cell Survival / drug effects
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Ethylamines / chemistry
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Fruit / chemistry*
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Furans / analysis*
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Furans / chemistry
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Furans / pharmacology
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Humans
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Inhibitory Concentration 50
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Lignans / analysis*
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Lignans / chemistry
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Lignans / pharmacology
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Methylamines / chemistry
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Molecular Structure
Substances
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Antineoplastic Agents
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Butylamines
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Ethylamines
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Furans
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Lignans
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Methylamines
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methylamine
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arctigenin
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ethylamine