Abstract
Four new dammarane-type saponins, operculinosides A-D (1-4), were isolated from the aerial parts of Operculina turpethum, of which 1 and 2 are the first two dammarane-type triterpenoids having an oxymethyl group at C-24. Their structures were determined by spectroscopic analysis and acid hydrolysis. The absolute configuration of operculinoside A (1) was confirmed by X-ray crystallography. Compounds 1 and 3 showed significant protective activities against d-galactosamine-induced toxicity in L-02 human hepatic cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Convolvulaceae / chemistry*
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Crystallography, X-Ray
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Dammaranes
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Galactosamine / toxicity
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Hepatocytes / drug effects
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Humans
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Drugs, Chinese Herbal
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Saponins
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Triterpenes
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Galactosamine