This study describes the epidemiology of childhood invasive Haemophilus influenzae disease in England and Wales between 1994 and 2008. H. influenzae serotype b incidence was lowest in 1998 (0.26/100,000), rising to 1.8/100,000 in 2002 before falling to 0.27/100,000 in 2008. During this period, nontype b H. influenzae disease remained stable, but there was a small year-on-year increase (3.4%/y; 95% CI: 1.4-5.5%) in incidence.