Predictors of relapse of methicillin-resistant Staphylococcus aureus bacteremia after treatment with vancomycin

Kerry J Welsh; Kimberly A Skrobarcek; April N Abbott; Cole T Lewis; Mark C Kruzel; Evan M Lewis; Jeanelle M Gardiner; John F Mohr; Lisa Y Armitige; Audrey Wanger

doi:10.1128/JCM.05287-11

Predictors of relapse of methicillin-resistant Staphylococcus aureus bacteremia after treatment with vancomycin

J Clin Microbiol. 2011 Oct;49(10):3669-72. doi: 10.1128/JCM.05287-11. Epub 2011 Aug 24.

Authors

Kerry J Welsh¹, Kimberly A Skrobarcek, April N Abbott, Cole T Lewis, Mark C Kruzel, Evan M Lewis, Jeanelle M Gardiner, John F Mohr, Lisa Y Armitige, Audrey Wanger

Affiliation

¹ Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 2.210, Houston, TX 77030, USA.

Abstract

The risk factors for relapse of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia after vancomycin treatment are unknown. Diversilab typing was used to classify recurrent bacteremia as relapse or reinfection. Bacteremia for >7 days and staphylococcal cassette chromosome mec element (SCCmec) type II were independently associated with relapse of MRSA bacteremia after vancomycin treatment.

MeSH terms

Adolescent
Adult
Aged
Anti-Bacterial Agents / administration & dosage*
Bacteremia / diagnosis*
Bacteremia / drug therapy*
Bacteremia / microbiology
Genes, Bacterial
Humans
Methicillin-Resistant Staphylococcus aureus / classification
Methicillin-Resistant Staphylococcus aureus / genetics
Methicillin-Resistant Staphylococcus aureus / isolation & purification*
Middle Aged
Molecular Typing
Recurrence
Risk Factors
Vancomycin / administration & dosage*
Young Adult

Substances

Anti-Bacterial Agents
Vancomycin