Abstract
Over the last decade, genetic and cell biology studies have indicated that tumour growth is not only determined by malignant cancer cells themselves, but also by the tumour microenvironment. Cells present in the tumour microenvironment include fibroblasts, vascular, smooth muscle, adipocytes, immune cells and mesenchymal stem cells (MSC). The nature of the relationship between MSC and tumour cells appears dual and whether MSC are pro- or anti-tumorigenic is a subject of controversial reports. This review is focused on the role of MSC and bone marrow (BM) niches in cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Bone Marrow Cells / drug effects
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Bone Marrow Cells / pathology*
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Bone Marrow Cells / physiology
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Drug Resistance, Neoplasm / physiology
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Humans
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Mesenchymal Stem Cells / cytology
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Mesenchymal Stem Cells / drug effects
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Mesenchymal Stem Cells / pathology*
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Mesenchymal Stem Cells / physiology
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Neoplasm Metastasis
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Neoplasms / drug therapy
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Neoplasms / pathology*
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Stem Cell Niche / drug effects
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Stem Cell Niche / physiology*
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / physiology