Synchronous epithelial and neuroendocrine cancers of the pancreas: case series of a rare occurrence

Derek G Power; Jinru Shia; Peter J Allen; William R Jarnagin; Eileen M O'Reilly

doi:10.1016/j.clcc.2011.03.013

Synchronous epithelial and neuroendocrine cancers of the pancreas: case series of a rare occurrence

Clin Colorectal Cancer. 2011 Jun;10(2):146-50. doi: 10.1016/j.clcc.2011.03.013. Epub 2011 Apr 27.

Authors

Derek G Power¹, Jinru Shia, Peter J Allen, William R Jarnagin, Eileen M O'Reilly

Affiliation

¹ Department of Medicine, Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

PMID: 21859569
DOI: 10.1016/j.clcc.2011.03.013

Abstract

The presence of neuroendocrine cells in adenocarcinomas is not an unusual finding and is well described in gastrointestinal tract cancers, eg, colorectal cancer and gastric cancer. Genetic analysis of such tumors has suggested a common multipotent progenitor stem cell origin. The prognostic significance of neuroendocrine cells in adenocarcinoma cells is unclear. There is a scant literature on synchronous pancreas ductal adenocarcinoma and pancreas neuroendocrine tumors. We report 2 cases with a purpose of discussing management strategies, prognosis, and potential etiologies of this rare presentation.

Publication types

Case Reports

MeSH terms

Carcinoma, Pancreatic Ductal / pathology*
Carcinoma, Pancreatic Ductal / physiopathology
Carcinoma, Pancreatic Ductal / therapy
Humans
Male
Middle Aged
Neoplasms, Multiple Primary / pathology*
Neoplasms, Multiple Primary / physiopathology
Neoplasms, Multiple Primary / therapy
Neuroendocrine Tumors / pathology*
Neuroendocrine Tumors / physiopathology
Neuroendocrine Tumors / therapy
Pancreatic Neoplasms / pathology*
Pancreatic Neoplasms / physiopathology
Pancreatic Neoplasms / therapy