cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

Cristina Airoldi; Francisco Cardona; Erika Sironi; Laura Colombo; Mario Salmona; Artur Silva; Francesco Nicotra; Barbara La Ferla

doi:10.1039/c1cc13046c

cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

Chem Commun (Camb). 2011 Oct 7;47(37):10266-8. doi: 10.1039/c1cc13046c. Epub 2011 Aug 22.

Authors

Cristina Airoldi¹, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Artur Silva, Francesco Nicotra, Barbara La Ferla

Affiliation

¹ Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126, Milan, Italy.

PMID: 21858375
DOI: 10.1039/c1cc13046c

Abstract

A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amyloid beta-Peptides / metabolism*
Benzopyrans / chemistry*
Benzopyrans / metabolism*
Ligands
Protein Binding
Stereoisomerism

Substances

Amyloid beta-Peptides
Benzopyrans
Ligands