Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

Jin Woo Bae; Ryan M Pearson; Niladri Patra; Suhair Sunoqrot; Lela Vuković; Petr Král; Seungpyo Hong

doi:10.1039/c1cc14331j

Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

Chem Commun (Camb). 2011 Oct 7;47(37):10302-4. doi: 10.1039/c1cc14331j. Epub 2011 Aug 22.

Authors

Jin Woo Bae¹, Ryan M Pearson, Niladri Patra, Suhair Sunoqrot, Lela Vuković, Petr Král, Seungpyo Hong

Affiliation

¹ Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood St. Chicago, IL 60612, USA.

Abstract

PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

This journal is © The Royal Society of Chemistry 2011

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dendrimers / chemistry*
Hydrophobic and Hydrophilic Interactions
Micelles
Molecular Conformation
Molecular Dynamics Simulation
Polyethylene Glycols / chemistry*

Substances

Dendrimers
Micelles
Polyethylene Glycols

Abstract

Publication types

MeSH terms

Substances

Grants and funding