Abstract
A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.
This journal is © The Royal Society of Chemistry 2011
MeSH terms
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Catalysis
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Mesylates / chemistry*
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Organometallic Compounds / chemistry*
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Quinazolinones / chemical synthesis*
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Quinazolinones / chemistry*
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Quinazolinones / pharmacology
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Mesylates
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Organometallic Compounds
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Quinazolinones
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Tumor Necrosis Factor-alpha
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ytterbium(III) triflate