Abstract
Three novel inosine-based dinuclear platinum complexes have been synthesized via a solid-phase strategy. In these compounds, the metal is linked both to the N-7 of the purine nucleus and to the terminal amine group of a hexylamine side chain installed on N-1. Cis- or trans- diamine as well as ethylenediamine ligands are coordinated to platinum along with a chloride. The synthesised complexes were tested against four different human tumor cell lines. One of these complexes proved to be more cytotoxic than cisplatin against the MCF7 cancer cell line in a short-term exposure assay.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antimetabolites, Antineoplastic / chemical synthesis*
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Antimetabolites, Antineoplastic / chemistry
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Antimetabolites, Antineoplastic / pharmacology*
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Antimetabolites, Antineoplastic / toxicity
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / toxicity
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Cell Line, Tumor
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Diamines / chemistry
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Drug Design
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Drug Screening Assays, Antitumor
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Female
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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Inosine / chemistry
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Molecular Structure
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Nucleosides / chemistry
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Platinum / chemistry
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Solid-Phase Synthesis Techniques*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Diamines
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Nucleosides
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Platinum
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Inosine