Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection

Antiviral Res. 2011 Nov;92(2):369-71. doi: 10.1016/j.antiviral.2011.08.003. Epub 2011 Aug 11.

Abstract

Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / administration & dosage*
  • Dengue / drug therapy*
  • Dengue / mortality
  • Dengue / pathology
  • Dengue / prevention & control*
  • Enzyme Inhibitors / administration & dosage*
  • Glycoside Hydrolase Inhibitors*
  • Mice
  • Survival Analysis
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors