A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent

ACS Appl Mater Interfaces. 2011 Sep;3(9):3325-34. doi: 10.1021/am200437r. Epub 2011 Sep 1.

Abstract

A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln(2)O(3) (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy(2)O(3) nanoparticle because it showed the highest r(2) relaxivity among studied nanoparticles. Its performance as a T(2) MRI contrast agent was for the first time proved in vivo through its 3 T T(2) MR images of a mouse, showing that it can be further exploited for the rational design of a new T(2) MRI contrast agent at high MR fields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Contrast Media / chemical synthesis*
  • Contrast Media / toxicity
  • Dysprosium / chemistry
  • Erbium / chemistry
  • Europium / chemistry
  • Gadolinium / chemistry
  • Glucuronic Acid / chemistry*
  • Holmium / chemistry
  • Kidney / diagnostic imaging
  • Lanthanoid Series Elements / chemistry*
  • Liver / diagnostic imaging
  • Magnetic Resonance Imaging
  • Male
  • Metal Nanoparticles / chemistry*
  • Mice
  • Mice, Inbred ICR
  • Radionuclide Imaging

Substances

  • Contrast Media
  • Lanthanoid Series Elements
  • Dysprosium
  • Europium
  • Erbium
  • Glucuronic Acid
  • Gadolinium
  • Holmium