Isolated metastatic tumor of the spleen is rare and usually encompass the presence of neoplasmatic dissemination. The most frequent location of metastasis is right lobe of the liver, however solitaire secondary tumor to distant organ such as brain, lung, bone marrow or other might be discovered. This report refers to the 15th case of isolated intrasplenic metastasis from colon and rectal cancer. Splenectomy is a method of choice therefore may be justified in presence of isolated metastatic disease, because of low complication rate, providing potential long-term survival.