Improved contrast deep optoacoustic imaging using displacement-compensated averaging: breast tumour phantom studies

Phys Med Biol. 2011 Sep 21;56(18):5889-901. doi: 10.1088/0031-9155/56/18/008. Epub 2011 Aug 18.

Abstract

For real-time optoacoustic (OA) imaging of the human body, a linear array transducer and reflection mode optical irradiation is usually preferred. Such a setup, however, results in significant image background, which prevents imaging structures at the ultimate depth determined by the light distribution and the signal noise level. Therefore, we previously proposed a method for image background reduction, based on displacement-compensated averaging (DCA) of image series obtained when the tissue sample under investigation is gradually deformed. OA signals and background signals are differently affected by the deformation and can thus be distinguished. The proposed method is now experimentally applied to image artificial tumours embedded inside breast phantoms. OA images are acquired alternately with pulse-echo images using a combined OA/echo-ultrasound device. Tissue deformation is accessed via speckle tracking in pulse echo images, and used to compensate in the OA images for the local tissue displacement. In that way, OA sources are highly correlated between subsequent images, while background is decorrelated and can therefore be reduced by averaging. We show that image contrast in breast phantoms is strongly improved and detectability of embedded tumours significantly increased, using the DCA method.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Compressive Strength
  • Contrast Media*
  • Female
  • Humans
  • Image Enhancement / instrumentation
  • Image Enhancement / methods*
  • Optical Devices*
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Shear Strength
  • Transducers
  • Ultrasonography, Mammary / instrumentation
  • Ultrasonography, Mammary / methods*

Substances

  • Contrast Media