Mathematical model of the primary CD8 T cell immune response: stability analysis of a nonlinear age-structured system

J Math Biol. 2012 Aug;65(2):263-91. doi: 10.1007/s00285-011-0459-8. Epub 2011 Aug 13.

Abstract

The primary CD8 T cell immune response, due to a first encounter with a pathogen, happens in two phases: an expansion phase, with a fast increase of T cell count, followed by a contraction phase. This contraction phase is followed by the generation of memory cells. These latter are specific of the antigen and will allow a faster and stronger response when encountering the antigen for the second time. We propose a nonlinear mathematical model describing the T CD8 immune response to a primary infection, based on three nonlinear ordinary differential equations and one nonlinear age-structured partial differential equation, describing the evolution of CD8 T cell count and pathogen amount. We discuss in particular the roles and relevance of feedback controls that regulate the response. First we reduce our system to a system with a nonlinear differential equation with a distributed delay. We study the existence of two steady states, and we analyze the asymptotic stability of these steady states. Second we study the system with a discrete delay, and analyze global asymptotic stability of steady states. Finally, we show some simulations that we can obtain from the model and confront them to experimental data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Computer Simulation
  • Immunologic Memory
  • Lymphocyte Activation / immunology
  • Lymphocytic Choriomeningitis / immunology*
  • Mice
  • Models, Immunological*
  • Nonlinear Dynamics*