Efficient sonochemical synthesis of alkyl 4-aryl-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate derivatives

Enrique Ruiz; Hortensia Rodríguez; Julieta Coro; Vladimir Niebla; Alfredo Rodríguez; Roberto Martínez-Alvarez; Hector Novoa de Armas; Margarita Suárez; Nazario Martín

doi:10.1016/j.ultsonch.2011.07.003

Efficient sonochemical synthesis of alkyl 4-aryl-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate derivatives

Ultrason Sonochem. 2012 Mar;19(2):221-6. doi: 10.1016/j.ultsonch.2011.07.003. Epub 2011 Jul 21.

Authors

Enrique Ruiz¹, Hortensia Rodríguez, Julieta Coro, Vladimir Niebla, Alfredo Rodríguez, Roberto Martínez-Alvarez, Hector Novoa de Armas, Margarita Suárez, Nazario Martín

Affiliation

¹ Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de La Habana, 10400-Ciudad Habana, Cuba.

PMID: 21840238
DOI: 10.1016/j.ultsonch.2011.07.003

Abstract

A facile, efficient and environment-friendly protocol for the synthesis of 6-chloro-5-formyl-1,4-dihydropyridine derivatives has been developed by the convenient ultrasound-mediated reaction of 2(1H)pyridone derivatives with the Vilsmeier-Haack reagent. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carboxylic Acids / chemical synthesis*
Carboxylic Acids / chemistry*
Chemistry Techniques, Synthetic / methods*
Green Chemistry Technology
Models, Molecular
Molecular Conformation
Ultrasonics*

Substances

Carboxylic Acids