The electronic transport properties of monolayer graphene with extreme physical deformation are studied using ab initio calculations. The aim is to explore the influence of physical bending on transport properties and identify the most important geometrical parameter. The transmission spectra are relatively insensitive to the geometrical parameters in low-energy regions-even in the extreme case of uniaxial bending. The results suggest that graphene, with its superb electromechanical robustness, could serve as a viable nanoscale material platform in a wide spectrum of applications such as photovoltaics, flexible electronics, and 3D carbon chips.