Lipid nanoparticles for brain targeting I. Formulation optimization

Int J Pharm. 2011 Oct 31;419(1-2):287-95. doi: 10.1016/j.ijpharm.2011.07.035. Epub 2011 Jul 28.

Abstract

The aim of this study was to optimize the formulation of lipid nanoparticles (NPs), intended for brain targeting, with the aid of a computer generated experimental design. The high pressure homogenization technique, selected for this purpose, was suitable to formulate the 3 investigated lipids (i.e., Softisan(®) 142, SOFT; Compritol(®) 888 ATO, COMP; cetyl palmitate, CP) into nanometre-length particles, while the computer generated experimental design helped to individuate the best preparation conditions with a small number of experimental assay. Even though all the 3 optimized formulations were suitable for intravenous infusion, CP NPs showed the smallest particle size and the appropriate thermal behaviour to be used as carriers in brain targeting applications.

Publication types

  • Comparative Study

MeSH terms

  • Brain / metabolism*
  • Computer-Aided Design
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Fatty Acids / chemistry
  • Infusions, Intravenous
  • Lipids / chemistry*
  • Nanoparticles*
  • Palmitates / chemistry
  • Particle Size
  • Temperature
  • Triglycerides / administration & dosage*
  • Triglycerides / chemistry

Substances

  • Drug Carriers
  • Fatty Acids
  • Lipids
  • Palmitates
  • Triglycerides
  • glyceryl behenate
  • cetyl palmitate