Pharmaceutical cocrystals: an overview

Int J Pharm. 2011 Oct 31;419(1-2):1-11. doi: 10.1016/j.ijpharm.2011.07.037. Epub 2011 Aug 2.

Abstract

Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation methods, physicochemical property studies, characterisation techniques, and recent theoretical developments in cocrystal screening and mechanisms of cocrystal formations. Examples of pharmaceutical cocrystals are also summarised in this paper.

Publication types

  • Review

MeSH terms

  • Crystallization
  • Drug Design*
  • Molecular Structure
  • Pharmaceutical Preparations / chemistry*
  • Solubility

Substances

  • Pharmaceutical Preparations