Abstract
A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia (CAP) were analyzed. Thirty percent showed a close relationship to international clones and had fitness equal to or exceeding that of other strains (P = 0.015); these factors may result in the endurance of these strains despite a reduction of antibiotic usage.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Community-Acquired Infections / drug therapy
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Community-Acquired Infections / epidemiology
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Community-Acquired Infections / microbiology
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Drug Resistance, Multiple, Bacterial*
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Humans
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Multilocus Sequence Typing
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Pneumonia, Pneumococcal / drug therapy
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Pneumonia, Pneumococcal / epidemiology
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Pneumonia, Pneumococcal / microbiology*
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Serotyping
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / isolation & purification
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Streptococcus pneumoniae / physiology*